{"id":1092,"date":"2020-06-18T16:08:47","date_gmt":"2020-06-18T14:08:47","guid":{"rendered":"https:\/\/www.inositoli.it\/acne-a-support-from-myo-inositol\/"},"modified":"2020-09-01T12:34:52","modified_gmt":"2020-09-01T10:34:52","slug":"acne-a-support-from-myo-inositol","status":"publish","type":"post","link":"https:\/\/www.inositoli.com\/en\/acne-a-support-from-myo-inositol\/","title":{"rendered":"Acne: a support from myo-inositol"},"content":{"rendered":"\n\n[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Introduction<\/h2>\r\n<strong>Acne<\/strong>, once considered as a purely aesthetic problem, is now recognized as a real dermatological disease which, depending on the severity, can cause more serious ailments, as well as having an important psychological and emotional impact for those suffering from it.\r\n\r\nAlthough it is a widespread condition, especially in the <strong>adolescent phase<\/strong>, acne can also occur in <strong>old age<\/strong>. <strong>Women<\/strong> are the ones most affected by <strong>late acne<\/strong> precisely because of hormonal imbalances and, in particular, the <strong>excess of testosterone<\/strong>, the most powerful of the natural male hormones (androgens).[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/acne-older-age.png&#8221; _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243; title_text=&#8221;acne-older-age&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.3.3&#8243;]Today, there are several<strong> treatments for acne<\/strong>. Among the pharmacological treatments, for women with hormonal imbalances, contraceptive pill is used. Antiandrogens can also be prescribed to minimize the effects of testosterone excess and therefore the onset of acne.\r\n\r\nRecent studies have investigated the <strong>benefits of using inositol in reducing testosterone levels and inflammation caused by acne.<\/strong>\r\n\r\nIn this article we will analyze exactly what are <strong>the results of myo-inositol-based therapies on acne.<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>What is acne?<\/h2>\r\nAcne is a real <strong>inflammation that occurs when the hair follicles are blocked by an excess of sebum<\/strong>, an oily substance produced by the sebaceous glands. This excess may be due to a more <strong>intense hormonal stimulation<\/strong>. It is then that acne manifests itself with the presence of whiteheads, blackheads and pimples on areas of the body sensitive to hormonal imbalances: face (mainly chin and forehead), but also back and shoulders. <strong>Acne usually appears during adolescence, but it can affect people of all ages.<\/strong>\r\n\r\nDepending on its severity, acne can cause emotional distress or deep scarring on the skin.[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/what-is-acne.png&#8221; _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243; title_text=&#8221;what-is-acne&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Acne symptoms<\/h2>\r\nAcne signs and symptoms can vary depending on the severity of the condition, presenting:\r\n<ul>\r\n \t<li><strong>Whiteheads:<\/strong> closed plugged pores<\/li>\r\n \t<li><strong>Blackheads:<\/strong> open plugged pores<\/li>\r\n \t<li><strong>Red bumps<\/strong> (papules)<\/li>\r\n \t<li><strong>Pimples<\/strong> (pustules)<\/li>\r\n \t<li>Solid and painful <strong>lumps beneath the surface of the skin<\/strong><\/li>\r\n \t<li><strong>Painful pus-filled lumps<\/strong> (cystic lesions)<\/li>\r\n<\/ul>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Types of acne<\/h2>\r\nDepending on the prevalence of the lesions, we can distinguish between <strong>different types of acne<\/strong>. Among the most common types there are:\r\n<ul>\r\n \t<li>the <strong>mild or comedonal<\/strong> one that generally affects the T-zone of the face (forehead, nose and chin), characterized by the presence of black, white and sporadic papules.<\/li>\r\n \t<li><strong>Papulo-pustular<\/strong> acne is a moderate or severe form of acne. The skin appears red and inflamed. This is also the most frequent form of acne.<\/li>\r\n \t<li><strong>Acne conglobata<\/strong> is the most severe form of acne with nodular-cystic lesions. This type of acne can manifest itself during puberty, but persist over the years.<\/li>\r\n<\/ul>[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/types-of-acne.png&#8221; _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243; title_text=&#8221;types-of-acne&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Acne: causes at a young age<\/h2>\r\nUsually acne occurs <strong>during adolescence<\/strong>, between 12 and 18 years, when hormonal changes typical of this phase of life occur. In this case, we talk about <strong>juvenile acne<\/strong>. Indeed, it is precisely the hormones that regulate the sebaceous glands functioning. <strong>Androgens, especially when in excess, stimulate the overproduction of sebum (known as seborrhea).<\/strong>\r\n\r\nIn most cases, acne tends to improve or otherwise disappear after puberty. However, over 40% of adults, and especially women, continue to suffer from acne even after adolescence.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Acne in adulthood<\/h2>\r\n<strong>Many women aged between 20 and 40 suffer from late female acne.<\/strong>\r\n\r\n<strong>An estimated 15% of women experience acne after 25 years of age, compared with 4% of adult males [1].<\/strong> This is because, unlike men, women are more prone to hormonal changes: just think about the menstrual cycle, but also the pregnancy and the menopause.\r\n\r\nAmong the causes of acne, in addition to hormonal imbalances, bad habits and environmental factors can occur, such as stress, pollution, smoking, but also a constitutional predisposition.\r\n\r\nHowever, hormonal imbalances are precisely the main cause of female acne.\r\n\r\nAmong these, <strong>PCOS or polycystic ovary syndrome is a hormonal and endocrine disorder that has acne among its most evident manifestations.<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Acne in the PCOS woman<\/h2>\r\nPolycystic ovary syndrome or PCOS in its English acronym is the most common endocrine disorder in women of reproductive age. The syndrome is generally characterized by <strong>hyperandrogenism<\/strong> (excess of male hormones), anovulation and multifollicular ovary. <strong>As previously said, women with PCOS often present hyperandrogenism dermatological manifestations, including acne [2].<\/strong>[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/pcos-what-is-it.png&#8221; _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243; title_text=&#8221;pcos-what-is-it&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>The action of myo-inositol on hormonal balance<\/h2>\r\nThere is now a vast scientific literature supporting the fact that <strong>myo-inositol<\/strong>, a substance naturally present in our body, plays <strong>a key role in the hormonal balance<\/strong> of our body, as a modulator of the signaling of indispensable hormones, such as insulin, FSH and even TSH.\r\nAt the same time, studies on this molecule have shown how it can <strong>improve testosterone levels in the blood<\/strong>. In the presence of hyperandrogenism, we know that there is an increase in testosterone: this stimulates the sebaceous glands, which produce more sebum and therefore acne.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Myo-inositol the benefits for acne<\/h2>\r\nSeveral scientific studies have investigated the role of inositol in the treatment of acne in women with PCOS.\r\n\r\nIn particular, <strong>an Italian trial enrolled 50 female patients and divided them into 2 groups [3]:<\/strong>\r\n<ul>\r\n \t<li><strong>group A<\/strong>, oral administration of <strong>2 grams of myo-inositol<\/strong>, twice a day for 6 months.<\/li>\r\n \t<li><strong>Group B<\/strong> as <strong>placebo group<\/strong> (200 micrograms of placebo, twice a day for 6 months).<\/li>\r\n<\/ul>\r\nAll patients returned to control three months after the start of therapy.\r\n\r\n<strong>The results of the study show that patients of group A who had taken myo-inositol showed a clear improvement of their acne.<\/strong>\r\n\r\nIn particular, in these patients, papulo-pustular lesions were significantly reduced, as was inflammation. The assessment of the severity of acne lesions was performed on the basis of the GEA (Global Evaluation of Acne) [3].\r\n\r\nIn contrast, in the placebo group, only 2 patients showed some improvement.\r\n\r\n<strong>In addition, in group A patients, serum levels of Dehydroepiandrosterone (DHEA), a steroid hormone acting on the androgen receptor, were reduced.<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Conclusions<\/h2>\r\nIn conclusion, study&#8217;s results suggest that inositol represents an effective therapy in the treatment of women with acne.\r\n\r\nInositol also plays a specific key role in reducing serum testosterone levels and in controlling both fats and sugars metabolism.\r\n\r\n<strong>Given these premises, inositol is useful in preventing and correcting the pathophysiological mechanisms underlying the acne-inducing metabolic alterations.<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<h2>Sources<\/h2>\r\n<p>[1] AIDECO, Associazione italiana dermatologia e cosmetologia<br \/><a href=\"https:\/\/www.aideco.org\/acne-facciamo-il-punto\">https:\/\/www.aideco.org\/acne-facciamo-il-punto<\/a><\/p>\r\n<p>[2] Skin Therapy Lett. 2010, Polycystic ovary syndrome and acne. Chuan SS1, Chang RJ]<\/p>\r\n<p>[3] Pezza M, Carlomagno V (2017) Inositol in women suffering from acne and PCOS: a randomized study. Glob Dermatol 4: doi: 10.15761\/GOD.1000203<br \/><a href=\"https:\/\/www.oatext.com\/Inositol-in-women-suffering-from-acne-and-PCOS-a-randomized-study.php#jumpmenu8\">https:\/\/www.oatext.com\/Inositol-in-women-suffering-from-acne-and-PCOS-a-randomized-study.php#jumpmenu8<\/a><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-center kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;center&quot;,&quot;id&quot;:&quot;1092&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;14&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;3.7&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate this post&quot;,&quot;legend&quot;:&quot;3.7\\\/5 - 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(14 votes)    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Acne, once considered as a purely aesthetic problem, is now recognized as a real dermatological disease which, depending on the severity, can cause more serious ailments<\/p>\n","protected":false},"author":1,"featured_media":1197,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,22],"tags":[],"class_list":["post-1092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-myo-inositol","category-pcos-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Acne: a support from myo-inositol - Inositoli<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.inositoli.com\/en\/acne-a-support-from-myo-inositol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acne: a support from myo-inositol - 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