{"id":1077,"date":"2020-06-18T13:27:46","date_gmt":"2020-06-18T11:27:46","guid":{"rendered":"https:\/\/www.inositoli.it\/401-2\/"},"modified":"2020-09-01T15:40:15","modified_gmt":"2020-09-01T13:40:15","slug":"myo-d-chiro-401","status":"publish","type":"page","link":"https:\/\/www.inositoli.com\/en\/myo-d-chiro-401\/","title":{"rendered":"40:1"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.3.1&#8243; border_width_bottom=&#8221;20px&#8221; border_color_bottom=&#8221;#E9E9E9&#8243;][et_pb_fullwidth_slider module_class=&#8221;x-intro-slider&#8221; _builder_version=&#8221;4.3.3&#8243; background_enable_color=&#8221;off&#8221;][et_pb_slide _builder_version=&#8221;4.3.3&#8243; background_color=&#8221;#266194&#8243; background_enable_color=&#8221;on&#8221; background_enable_image=&#8221;off&#8221; text_orientation=&#8221;left&#8221;]<\/p>\n<h1>The true story of MYO and D-Chiro 40:1<\/h1>\n<p>[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.3.1&#8243; custom_padding=&#8221;29px|||||&#8221;][et_pb_row _builder_version=&#8221;4.3.1&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-index has-chip has-chip&#8211;left&#8221; _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>Index<\/h2>\n<ol>\n<li><a href=\"#introduzione\">Introduction<\/a><\/li>\n<li><a href=\"#punto-di-arrivo\">40:1, an arrival point<\/a><\/li>\n<li><a href=\"#ruolo-inositolo-trattamento-pcos\">The role of inositols in the treatment of PCOS<\/a><\/li>\n<li><a href=\"#inositoli-confronto\">Myo and D-chiro: comparison of inositols<\/a><\/li>\n<li><a href=\"#paradosso-ovarico-pcos\">The ovarian paradox in PCOS<\/a><\/li>\n<li><a href=\"#questione-di-equilibrio\">Myo and d-chiro 40:1, a question of balance<\/a><\/li>\n<li><a href=\"#benefici-iperandrogenismo\">The benefits on hyperandrogenism<\/a><\/li>\n<li><a href=\"#benefici-ovulazione-fertilita\">The benefits on ovulation and fertility<\/a><\/li>\n<li><a href=\"#benefici-morfologia-ovaio-policistico\">The benefits on the morphology of the polycystic ovary<\/a><\/li>\n<li><a href=\"#benefici-profilo-metabolico\">The benefits on the metabolic profile<\/a><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;introduzione&#8221; _builder_version=&#8221;4.3.3&#8243; custom_padding=&#8221;0px||0px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<h2>Introduction<\/h2>\n<p>Among the questions that most interest the scientific debate on inositols there is probably the one related to: <strong><em>&#8220;Myo-inositol, D-chiro-inositol or both for PCOS?&#8221;<\/em><\/strong><\/p>\n<blockquote>\n<p><strong><em>It is good that the answer to this question comes from science and clinical evidence. The different roles that myo and d-chiro-inositol play at physiological level tell us which the most suitable path is.<\/em><\/strong><\/p>\n<\/blockquote>\n<p>On this page, <strong>we will talk about the true story of the scientific research on inositols and explain why and in which cases the combination of <a href=\"\/en\/myo-inositol\/\"><u>myo-inositol<\/u><\/a> and <a href=\"\/en\/d-chiro\/\"><u>d-chiro-inositol<\/u><\/a> in the 40:1 ratio is the best choice for PCOS women.<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;punto-di-arrivo&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2><b>40:1 an arrival point<\/b><\/h2>\n<p>Along the history of the use of inositols in clinical practice, <strong>the combined therapeutic formula of myo and d-chiro-inositol in the 40:1 ratio represents an important arrival point of a scientific research that takes its first steps already in the second half of the 1900,<\/strong> when the attention of researchers focused more and more on inositols.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;ruolo-inositolo-trattamento-pcos&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>The role of inositol in the treatment of PCOS<\/h2>\n<p>In recent years, an increasing number of studies have focused on the ability of inositols, especially myo-inositol and D-chiro-inositol, <strong>to improve ovulation and fertility of PCOS women.<\/strong><\/p>\n<blockquote><p>&nbsp;<\/p><\/blockquote>\n<p>[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/pcos-popultion.png&#8221; title_text=&#8221;pcos-popultion&#8221; _builder_version=&#8221;4.4.8&#8243;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<p>To learn more read: <a href=\"\/en\/pcos\/\"><strong><u>Inositols and PCOS<\/u><\/strong><\/a><\/p>\n<p>Clinical data have shown that myo and d-chiro have an insulin sensitizing effect. <strong>There is therefore no doubt that both inositols perform essential functions for the body.<\/strong><\/p>\n<blockquote>\n<p><strong>So why 40:1? The answer is to be found not in the similarities, but in the differences between myo and d-chiro inositol.<\/strong><\/p>\n<\/blockquote>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;inositoli-confronto&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<h2>Myo and d-chiro: comparison of inositols<\/h2>\n<p>Already in <strong>1988<\/strong>, the scientist <strong>Larner first sensed that myo-inositol and D-chiro inositol were two different chemical mediators of insulin.<\/strong><\/p>\n<p>Although very similar, <strong>the functions of the two isomers are in fact different.<\/strong><\/p>\n<p>Summing up:<\/p>\n<ul>\n<li><strong>myo-inositol<\/strong> increases <strong>the glucose<\/strong> <strong>cellular uptake <\/strong>and is involved in the <strong>FSH activity [1];<\/strong><\/li>\n<li>instead, <strong>D-chiro-inositol<\/strong> is crucial for the <strong>glycogen synthesis <\/strong>and participates in <strong>the androgens production at ovarian level [1];<\/strong><\/li>\n<li><strong>D-chiro-inositol<\/strong> is found in <strong>high concentrations in the tissues that store glycogen<\/strong>: fat, liver and muscles;<\/li>\n<li>instead, <strong>myo-inositol<\/strong> is greater in tissues that need energy: <strong>heart, brain, ovaries and in follicular fluid in women, testicles and seminal fluid in men;<\/strong><\/li>\n<li>The physiological myo \/ D-chiro ratio and the relative quantities of each stereoisomer vary from tissue to tissue. In other words, <strong>myo and D-chiro ratio is &#8220;tissue-specific&#8221;.<\/strong><\/li>\n<\/ul>\n<blockquote>\n<p>The myo and d-chiro ratio is \u201ctissue-specific\u201d, thus reflecting the different physiological role of the two inositols [2] [3].<\/p>\n<\/blockquote>\n<p>To learn more we recommend: <a href=\"\/en\/the-difference-between-inositol-myo-inositol-and-d-chiro-inositol\/\"><strong><u>The difference between inositol<\/u>, <u>Myo-inositol and D-Chiro-inositol<\/u><\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;paradosso-ovarico-pcos&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>The ovarian paradox in PCOS<\/h2>\n<p>We said that in healthy women, <strong>the follicular fluid is rich in myo-inositol.<\/strong><\/p>\n<p>Scientific evidence has shown that <strong>in PCOS women, on the other hand, the ovary is rich in d-chiro. How can you explain this imbalance?<\/strong><\/p>\n<p>To answer this question, it is necessary to introduce the role of an enzyme, <strong>epimerase<\/strong>: this enzyme depends on the insulin hormone and is responsible for the conversion of myo-inositol into d-chiro-inositol.<\/p>\n<p><strong>In PCOS women, in hyperinsulinemia conditions, epimerase activity is accelerated, causing excessive conversion of myo into D-chiro [4].<\/strong>[\/et_pb_text][et_pb_image src=&#8221;http:\/\/inositoli.it\/wp-content\/uploads\/2020\/09\/epimerase.png&#8221; title_text=&#8221;epimerase&#8221; _builder_version=&#8221;4.4.8&#8243;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<p>Unlike the other organs, the ovary is never insulin resistant and, in PCOS woman, it becomes rich in d-chiro inositol. <strong>Myo deficiency causes a negative effect on the FSH signal (follicle stimulating hormone) and on the oocyte quality [4].<\/strong><\/p>\n<p>To learn more about the &#8220;d-chiro paradox in PCOS&#8221; also read: <a href=\"\/en\/d-chiro\/\"><strong><u>D-chiro-inositol: what it is, use and benefits<\/u><\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;questione-di-equilibrio&#8221; _builder_version=&#8221;4.3.3&#8243; min_height=&#8221;451px&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>Myo and D-chiro 40:1: a question of balance<\/h2>\n<p>Starting from the intuition on the ovarian paradox, and the different roles that myo and d-chiro play, a group of Italian scientists focused the attention on the importance of a correct myo and D-chiro inositol supplementation, taking into account the need to restore the impairment by restoring the correct myo\/d-chiro ratio at ovarian level too.<\/p>\n<p><strong><em>But which is the optimal dosage to take advantage of the d-chiro-inositol efficacy without compromising the ovarian functionality?<\/em><\/strong><\/p>\n<blockquote><p>Considering the specific relationship between Myo and D-chiro inositol and the different physiological roles of both, the combined Myo and D-chiro oral therapy in the 40:1 ratio (the physiological ratio in the blood) has been proposed as an alternative and effective treatment for PCOS women [5].<\/p><\/blockquote>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;benefici-iperandrogenismo&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>Myo and D-chiro 40:1: the benefits on hyperandrogenism<\/h2>\n<p>The excess of androgens in PCOS can be explained through two mechanisms:<\/p>\n<ul>\n<li>insulin resistance;<\/li>\n<li>the impaired myo and D-chiro ratio in the ovary.<\/li>\n<\/ul>\n<p>It is for this reason that <strong>an increasing number of studies have focused on evaluating the combination of the two inositols as a treatment for PCOS<\/strong>. Among the various MI\/DCI ratios that have been tested, several studies concluded that <strong>the combination of myo and D-chiro 40:1 seems to be the best choice to restore the endocrinological impairments in overweight or obese PCOS women (BMI&gt; 25). [6].<\/strong><\/p>\n<blockquote><p>The combination of myo and D-chiro 40:1 seems to be the best choice to restore the endocrinological impairments in overweight or obese PCOS women 40:1<\/p><\/blockquote>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;benefici-ovulazione-fertilita&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>40:1 and the benefits on ovulation and fertility<\/h2>\n<p><strong>The International Consesus Conference<\/strong> in Florence on the use of myo and D-chiro in obstetrics and gynecology <strong>affirmed the beneficial effects of the 40:1 plasma ratio<\/strong> <strong>on the oocyte and ovarian quality <\/strong>[7]. Colazingari also in his study [8] demonstrated the <strong>advantages of the combined 40:1 ratio for oocyte quality compared to d-chiro inositol alone.<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;benefici-morfologia-ovaio-policistico&#8221; _builder_version=&#8221;4.3.3&#8243; min_height=&#8221;311px&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>40:1 and the benefits on the morphology of the polycystic ovary<\/h2>\n<p><strong>In PCOS women<\/strong>, in addition to the excessive conversion of myo into D-chiro and the lack of myo in the follicles [1],<strong> a positive correlation was also found between the volume of the follicular fluid, myo inositol and the presence of mature oocytes.<\/strong><\/p>\n<p>The administration of <strong>d-chiro-inositol alone, at high doses, has been shown to decrease oocyte quality and ovarian response<\/strong> [9]. <strong>On the contrary, the best results were obtained with the combination of Myo and d-chiro<\/strong> [10].<\/p>\n<blockquote><p>A surprising study on a mouse model shows how the PCOS treatment with Myo D-chiro 40:1 has allowed the ovaries to return to their histological characteristics and to restore fertility [11].<\/p><\/blockquote>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row module_id=&#8221;benefici-profilo-metabolico&#8221; _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.4.8&#8243; custom_padding=&#8221;1px|||||&#8221; hover_enabled=&#8221;0&#8243;]<\/p>\n<h2>40:1 and the metabolic benefits<\/h2>\n<p><strong>Insulin resistance and the consequent compensatory hyperinsulinemia <\/strong>are frequent <strong>dysfunctions in PCOS women<\/strong>, regardless of body weight, but with a prevalence in association with obesity.<\/p>\n<p><strong>This is a wake-up call for cardiovascular risk<\/strong> and the development of other serious diseases, including type 2 diabetes, hypertension and metabolic syndrome [12].<\/p>\n<blockquote>\n<p>Studies have shown that Myo\/D-chiro 40:1 therapy has improved LDL, HDL and TG (triglyceride) levels, while also reducing fasting and circulating insulin levels.<\/p>\n<\/blockquote>\n<p>To learn more, read also: <a href=\"\/en\/overweight\/\"><strong><u>Inositols, overweight and obesity<\/u><\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.3.3&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.3&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243;]<\/p>\n<h2>Sources<\/h2>\n<p>[1] Nestler, J.E.; Unfer, V. Reflections on Inositol(s) for PCOS Therapy: Steps toward Success. Gynecol. Endocrinol. 2015, 31, 501\u2013505;<\/p>\n<p>[2] Facchinetti, F.; Orr\u00f9, B.; Grandi, G.; Unfer, V. Short-Term Effects of Metformin and Myo-Inositol in Women with Polycystic Ovarian Syndrome (PCOS): A Meta-Analysis of Randomized Clinical Trials. Facchinetti F1, Orr\u00f9 B2, Grandi G1, Unfer V3. Gynecol. Endocrinol. 2019, 35, 198\u2013206<\/p>\n<p>[3] Lagan\u00e0, A.S.; Rossetti, P.; Buscema, M.; La Vignera, S.; Condorelli, R.A.; Gullo, G.; Granese, R.; Triolo, O. Metabolism and Ovarian Function in PCOSWomen: ATherapeutic Approach with Inositols. Int. J. Endocrinol. 2016, 2016, 6306410.<\/p>\n<p>[4] Unfer V, Carlomagno G, Papaleo E, Vailati S, Candiani M, Baillargeon JP. Hyperinsulinemia Alters Myoinositol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reprod Sci. 2014;21(7):854-8.<\/p>\n<p>[5] Unfer, V.; Facchinetti, F.; Orr\u00f9, B.; Giordani, B.; Nestler, J. Myo-Inositol Effects in Women with PCOS: A Meta-Analysis of Randomized Controlled Trials. Endocr. Connect. 2017, 6, 647\u2013658.<\/p>\n<p>[6] Benelli, E.; Del Ghianda, S.; Di Cosmo, C.; Tonacchera, M. A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Int. J. Endocrinol. 2016, 2016, 3204083<\/p>\n<p>[7] Bevilacqua, A.; Carlomagno, G.; Gerli, S.; Oliva, M.M.; Devroey, P.; Lanzone, A.; Soulange, C.; Facchinetti, F.; Di Renzo, G.C.; Bizzarri, M.; et al. Results from the International Consensus Conference on Myo-Inositol and D-Chiro-Inositol in Obstetrics and Gynecology-Assisted Reproduction Technology. Gynecol. Endocrinol. 2015, 31, 441\u2013446.<\/p>\n<p>[8] Colazingari, S.; Treglia, M.; Najjar, R.; Bevilacqua, A. The Combined Therapy Myo-Inositol plus D-Chiro-Inositol, Rather than D-Chiro-Inositol, Is Able to Improve IVF Outcomes: Results froma Randomized Controlled Trial. Arch. Gynecol. Obstet. 2013, 288, 1405\u20131411.<\/p>\n<p>[9] Ravanos K, Monastra G, Pavlidou T, Goudakou M, Prapas N. Can high levels of D-chiro-inositol in follicular fluid exert detrimental effects on blastocyst quality? European review for medical and pharmacological sciences. 2017;21(23):5491-8.<\/p>\n<p>[10] Dinicola, S.; Chiu, T.T.Y.; Unfer, V.; Carlomagno, G.; Bizzarri, M. The Rationale of the Myo-Inositol and D-Chiro-Inositol Combined Treatment for Polycystic Ovary Syndrome. J. Clin. Pharmacol. 2014, 54, 1079\u20131092<\/p>\n<p>[11] Bevilacqua, A.; Dragotto, J.; Giuliani, A.; Bizzarri, M. Myo-Inositol and D-Chiro-Inositol (40:1) Reverse<br \/>\nHistological and Functional Features of Polycystic Ovary Syndrome in a Mouse Model. J. Cell. Physiol. 2019,<br \/>\n234, 9387\u20139398.<\/p>\n<p>[12] Diamanti-Kandarakis, E.; Dunaif, A. Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications. Endocr. Rev. 2012, 33, 981\u20131030.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.2&#8243; background_color=&#8221;#0d7d70&#8243; custom_padding=&#8221;0px||1px|||&#8221;][et_pb_row _builder_version=&#8221;4.3.1&#8243; custom_padding=&#8221;36px||0px|||&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text _builder_version=&#8221;4.3.3&#8243; header_2_font_size=&#8221;40px&#8221; background_layout=&#8221;dark&#8221; header_2_font_size_tablet=&#8221;35px&#8221; header_2_font_size_phone=&#8221;28px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221;]<\/p>\n<h2>Other topics that may interest you<\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-home-explore c-home-explore&#8211;1&#8243; _builder_version=&#8221;4.4.2&#8243; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#489bd6&#8243; text_font_size=&#8221;34px&#8221; background_color=&#8221;#ebf5fb&#8221; custom_padding=&#8221;40px||40px||false|false&#8221; link_option_url=&#8221;http:\/\/inositoli.it\/en\/myo-inositol\/&#8221;]<\/p>\n<p style=\"text-align: center;\">Myo-inositol<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-home-explore c-home-explore&#8211;2&#8243; _builder_version=&#8221;4.4.2&#8243; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#fab517&#8243; text_font_size=&#8221;34px&#8221; background_color=&#8221;#fff7ea&#8221; custom_padding=&#8221;40px||40px||false|false&#8221; link_option_url=&#8221;http:\/\/inositoli.it\/en\/d-chiro\/&#8221;]<\/p>\n<p style=\"text-align: center;\">D-chiro-inositol<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-home-explore c-home-explore&#8211;4&#8243; _builder_version=&#8221;4.4.2&#8243; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#26336b&#8221; text_font_size=&#8221;34px&#8221; background_color=&#8221;#e9ebf1&#8243; custom_padding=&#8221;40px||40px||false|false&#8221; link_option_url=&#8221;http:\/\/inositoli.it\/en\/%ce%b1-la\/&#8221;]<\/p>\n<p style=\"text-align: center;\">Alpha-lactalbumin<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-home-explore c-home-explore&#8211;5&#8243; _builder_version=&#8221;4.4.2&#8243; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#af1551&#8243; text_font_size=&#8221;34px&#8221; background_color=&#8221;#f6e8ee&#8221; custom_padding=&#8221;40px||40px||false|false&#8221; link_option_url=&#8221;http:\/\/inositoli.it\/en\/pcos-2\/&#8221;]<\/p>\n<p style=\"text-align: center;\">PCOS<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][et_pb_text module_class=&#8221;c-home-explore c-home-explore&#8211;6&#8243; _builder_version=&#8221;4.4.2&#8243; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#e04c12&#8243; text_font_size=&#8221;34px&#8221; background_color=&#8221;#fceee9&#8243; custom_padding=&#8221;40px||40px||false|false&#8221; link_option_url=&#8221;http:\/\/inositoli.it\/en\/overweight\/&#8221;]<\/p>\n<p style=\"text-align: center;\">Overweight<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.3.1&#8243;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The true story of MYO and D-Chiro 40:1Index Introduction 40:1, an arrival point The role of inositols in the treatment of PCOS Myo and D-chiro: comparison of inositols The ovarian paradox in PCOS Myo and d-chiro 40:1, a question of balance The benefits on hyperandrogenism The benefits on ovulation and fertility The benefits on the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1077","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - 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